Diabetes may be linked to hearing loss: study

(Reuters) - Diabetes has already been tied to an increased risk of kidney and cardiovascular troubles, nerve damage and vision loss, and now a Japanese study finds diabetics to be more than twice as likely as those without the disease to have hearing impairment.

In a review of past research on the issue, published in the Journal of Clinical Endocrinology and Metabolism, scientists found that younger diabetics were at even higher risk than older adults, though they could not explain why.

"Current meta-analysis suggests that the higher prevalence of hearing impairment in diabetic patients compared with nondiabetic patients was consistent regardless of age," wrote lead researcher Chika Horikawa, at Niigata University Faculty of Medicine, and colleagues.

It's not the first time researchers have found a link between diabetes and hearing loss. In 2008, researchers from the U.S. National Institutes of Health (NIH) saw similar patterns in a sample of more than 11,000 people, with people with diabetes twice as likely to have hearing loss as those without.

It's thought that high blood sugar levels brought on by diabetes may lead to hearing loss by damaging blood vessels in the ears, said Horikawa.

Horikawa and colleagues collected information from 13 previous studies examining the link between diabetes and hearing loss and published between 1977 and 2011. Together, the data covered 7,377 diabetes and 12,817 people without the condition.

Overall, Horikawa's team found that diabetics were 2.15 times as likely as people without the disease to have hearing loss. But when the results were broken down by age, people under 60 had 2.61 times the risk while people over 60 hand 1.58 times higher risk.

Some experts caution that this kind of study does not prove that diabetes is directly responsible for the greater hearing loss rates.

"It doesn't definitively answer the question, but it continues to raise an important point that patients might ask about," said Steven Smith, a diabetes specialist at the Mayo Clinic in Rochester, Minnesota.

The researchers note that future studies that take more factors into account, such as age and noisy environment, are needed to clarify the link between diabetes and hearing loss.

Still, Horikawa told Reuters Health in an email, people should recognize that diabetics may be at risk for hearing loss based on their results.

"Furthermore, these results propose that diabetic patients are screened for hearing impairment from (an) earlier age compared with non-diabetics," said Horikawa, adding that hearing loss has also been linked to an increased risk of depression and dementia. SOURCE: http:.//bit.ly/RIVeeW

(Reporting from New York by Andrew Seaman at Reuters Health; editing by Elaine Lies)

Source: http://news.yahoo.com/diabetes-may-linked-hearing-loss-study-234602205.html

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Kazakhstan lauds leader on new holiday

ALMATY, Kazakhstan (AP) ? Kazakhstan is observing a new holiday lauding President Nursultan Nazarbayev, part of a growing cult of personality around the leader of the sprawling, resource-rich former Soviet republic.

The highlight of Saturday's celebration of President's Day, which marks the anniversary of Nazarbayev's first election in 1991, was a carefully choreographed pageant by some 30,000 performers in an arena in the capital Astana, including mass singing and banner-waving.

The 72-year-old Nazarbayev exercises extraordinary dominion over Kazakhstan's political life. In the most recent presidential election in 2010, he pushed aside three token rivals to win 95 percent of the vote. International monitors criticized the election as unfair.

He receives blanket, praiseful coverage from state news media, while the government has cracked down on independent outlets.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-12-01-AS-Kazakhstan-Hero-President/id-7d94a81e2ee64c1bbd7f9079704fe62d

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States wary of trade-offs in accepting Medicaid expansion for millions of low-income uninsured (Star Tribune)

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Paper Vernissage: Advent Calendar and the Story Behind It

Back in 1986 we lived in a four room house on four acres. ?We had already outgrown the house and were contemplating what to do when we were approached by a realtor who lived up the hill behind us to see if we wanted to sell off two of those acres. ?It took a lot of talking it out before we decided to go ahead and instead of putting the money we would make into fixing up the house for someone else to buy, to add on and up for ourselves. ?It was an eventful 8 months of that year between March and September. ?

Things kind of fell into place for us in that my grandmother had recently passed away and we were able to move into her part of the two-family house that my parents still lived in. ?The four of us slept in one room - HWNSNBP and myself in the bed, Chris on a mattress on the floor, and Rachel still in her crib. ?It was cramped but cozy. ? ?

We had hired someone to design the addition and do the framing and we did the contracting of the other work like plumbing, heating, and electric. ?The finishing of the inside was done by HWNSNBP and his band of buddies who spent many evenings and weekends putting in the sheetrock and other various jobs. ? There was still a lot of "finishing" work that had to be done when we moved back in in September, and truthfully, to this day there are still some things that have not been completed. ?But we added out and up and made a comfortable home for our family of four.

Paging through a book or craft magazine (I don't remember exactly where) I came upon and idea for an advent calendar and knew that we had the basic ingredients in the scrap wood pile.

I asked HWNSNBP to cut me a piece of plywood leftover from the subflooring in a rectangle about 20" x 12" and some one inch strips of 1x4 in lengths to frame it. ?I did a quick whitewash of the plywood rectangle and painted the frame red. ?The tree was dry-brushed with green paint and no pattern in one try - I think I got real luck with that. ?One more red strip of wood was needed for the ornament bar. ?Tiny brass nails were positioned on the tree and ornament bar - 24 on each.

On the back it was dated with our names as co-creators.

And each year from then until 2002 we kept track of the kids taking turns to start hanging the ornaments on the tree - beginning with the angel at the top.

There was a store called The Pink Sleigh in a town nearby that had all kinds of craft supplies as well as finished Christmas decorations. ?It was kind of like walking into an old candy store with bins of this and that and on top of one of the counters was a partitioned box that you could pick out the little "ingredients" for your crafts from. ?I had the kids, then 3 and 5, help me pick out 24 of the little wood and plastic figures and at home I meticulously glued the gold thread to the top of each one so they could become ornaments.

They get all lined up on the ornament bar with the angel first and the Baby Jesus last (one of the nails has gone missing which is why everything is pushed over one for now).

On December 1st we put it up and begin by hanging the angel at the top.

We're not keeping track of who goes first any more as the kids have moved out. ?It's basically who remembers first for the day that gets to put the ornament up now.

This advent season we are also trying something else that I had read about on someone's blog. ?We're trying to do a Random Acts of Kindness Advent. ?Beginning yesterday we will try to do something somewhat unexpected for someone each day. ?Nothing really big or too expensive. ?Just thoughtful. ?For instance - donating a book anonymously to the library, or sharing coupons at the store with the person behind us, paying for the next person's coffee, or leaving a little treat for the mailman or crossing guard or co-worker. ?We're still trying to come up with ideas, so if you have any, please feel free to share them - or perhaps, if not for the next 24 days, pick out a few days that you might like to RAK someone. ?

Source: http://papervernissage.blogspot.com/2012/12/advent-calendar-and-story-behind-it.html

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Novel studies of gene regulation in brain development may mean new treatment of mental disorders

ScienceDaily (Nov. 30, 2012) ? A team of researchers at the University of California, San Diego and the Institut Pasteur, Paris has come up with a novel way to describe a time-dependent brain development based on coherent-gene-groups (CGGs) and transcription-factors (TFs) hierarchy. The findings could lead to new drug designs for mental disorders such as autism-spectrum disorders (ASD) and schizophrenia.

In the paper, published November 22 as an online-first publication in the journal Genes, Brain and Behavior, the researchers identified the hierarchical tree of CGG-TF networks that determine the patterns of genes expressed during brain development and found that some "master transcription factors" at the top level of the hierarchy regulated the expression of a significant number of gene groups.

Instead of a taking the approach that a single gene creates a single response, researchers used contemporary methods of data analysis, along with the Gordon supercomputer at the university's San Diego Supercomputer Center (SDSC), to identify CGGs responsible for brain development which can be affected for treatment of mental disorders. The team found that these groups of genes act in concert to send signals at various levels of the hierarchy to other groups of genes, which control the general and more specific (depending of the level) events in brain structure development.

"We have proposed a novel, though still hypothetical, strategy of drug design based on this hierarchical network of TFs that could pave the way for a new category of pharmacological agents that could be used to block a pathway at a critical time during brain development as an effective way to treat and even prevent mental disorders such as ASD and schizophrenia," said lead author Igor Tsigelny, a research scientist with SDSC, as well as the university's Moores Cancer Center and Department of Neurosciences. "On a broader scale, these findings have the potential to change the paradigm of drug design."

Using samples taken from three different regions of the brains of rats, the researchers used Gordon and SDSC's BiologicalNetworks server to conduct numerous levels of analysis, starting with processing of microarray data and SOM (self-organizing maps) clustering, before determining which gene zones were associated with significant developmental changes and brain disorders.

Researchers then conducted analyses of stages of development and quick comparisons between rat and human brain development, in addition to pathway analyses and functional and hierarchical network analyses. The team then analyzed specific gene-TF interactions, with a focus on neurological disorders, before investigating further directions for drug design based on analysis of the hierarchical networks.

Tsigelny's collaborators included Valentina L. Kouzentsova (SDSC and Moores), Michael Baitaluk (SDSC); and Jean-Pierre Changeux, with the Institut Pasteur, in Paris, France. Changeux also is a Skaggs distinguished visiting professor in pharmacology at UC San Diego (2008) and a member of the foreign faculty at UC San Diego's Kavli Institute for Brain and Mind. In addition to SDSC and its computational resources, support for the research paper, called A Hierarchical Coherent-Gene-Group Model for Brain Development, was provided by National Institutes of Health grant # GM084881 for Baitaluk.

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The above story is reprinted from materials provided by University of California, San Diego, via Newswise.

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Journal Reference:

1. Igor F. Tsigelny, Valentina L. Kouznetsova, Michael Baitaluk, Jean-Pierre Changeux. A hierarchical coherent-gene-group model for brain development. Genes, Brain and Behavior, 2012; DOI: 10.1111/gbb.12005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/2X_nTUcu3Eg/121130151612.htm

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How to use iTunes 11's new features (with the old look)

55 min.

Thorin Klosowski , Lifehacker

Apple released its newest version of iTunes, and it's a complete overhaul to the entire program. As you'd?expect, that means there are a few cool (somewhat) hidden features. Here are some we've found especially helpful.

With any new iteration of software you're bound to have a bit of a learning curve as you get used to it.?iTunes? 11?is no different, and the first thing you're greeted to when you launch it is a completely different main screen. The big news with iTunes 11 is the new interface, but hidden beneath that is some pretty cool functionality you might not notice at first glance.

Yes, you can get the old iTunes look back (sidebar and all)
Let's start with what we're guessing is most people's main gripe: it looks different. It's true, it does, and if you're not a fan of browsing your music library with giant covers, and navigating drop-down menus, iTunes 11 is a bit annoying. The good news? You can get the old look back:

• Get the sidebar back by clicking View > Show Sidebar (or hitting Alt+Cmd+S).
• Get the status bar back by clicking View > Show Status Bar (or hit Command+/).
• Click Songs in the top bar, and sort by Artist for the traditional list view.

Now, iTunes 11 should look about the same as iTunes 10.

Scan iTunes gift cards with your camera
Entering?in the code from a gift?certificate is always a bit annoying. With iTunes 11, all you need is a camera:

• Head into the iTunes Store, and Click "Redeem" at the bottom of the screen under the "Manage" list (or?click this link)
• Click "Use Camera"
• Hold your gift card up to the camera and wait for it to register.

That's it! No more fumbling around typing a random string of letters and numbers together.

Expanded view replaces cover flow
Cover Flow is gone in iTunes 11 and it's replaced with the new "Expanded View." When you're viewing your library by Albums, simply select an album, and you get an expanded view right there with all the album info. It works a lot better than Cover Flow and makes it so you can quickly view album info without leaving the place you're at. You can either click the album art again, or the "X" in the right corner to make it go away.

Also, a fun fact: Expanded View uses the album artwork as a background for the view (see image at right), so it creates a different background for each album. You can disable this if you want under iTunes > Preferences > General Preferences. Just uncheck the "Use custom colors for open albums, movies, etc" box.

The 'up next' feature is actually awesome?
Ever have those moments where you're listening to a song and it reminds you of another song? You don't want to stop the song playing, but you do want to cue up the song you're thinking of. That's what "Up Next" lets you do. Instead of creating playlists for everything, you can create on-the-fly playlists of songs or albums.

You can do this from anywhere. Just right-click an album, artist, or song, click "Add to Up Next" and it's added to the queue. You can also click "Play Next" instead to add it to the top of the queue. To see what's in your queue, click the list button in the middle of iTunes, and to view the previously played tracks, click the little clock icon. "Up Next" replaces iTunes DJ/Party Shuffle, so if you're looking for those, you won't find them.

Your place is now saved across devices?
If you use a bunch of Apple products, say, an iPhone, iPad, and iPod Touch, one of the best new features in iTunes 11 is that it saves your progress in your media across all devices through iCloud. So, if you pause a movie, TV show, podcast, audiobook, or iTunes U file on your desktop, you can pick up right where you left off on another device.?

MiniPlayer is more functional
In older versions of iTunes, the MiniPlayer didn't do much except allow you to pause or skip tracks. Now, MiniPlayer allows you to search for new tracks, add new songs to the "Up Next" queue, and even control AirPlay volume.

To enable MiniPlayer, just click the window icon in the top right corner and iTunes will shrink down. When you mouse over the window, you can control playback or search for new tracks. Otherwise, it displays the currently playing track.

Preview history tracks what you listen to in the store?
The iTunes Store now tracks everything you listen to in its preview history panel. When you're in the store, click the list icon in the top right corner, and you're shown all the stuff you listened to recently. You can hit "Clear" to get rid of everything in the list Also worth noting is that provided you're signed in with iCloud, your previewed tracks on all your devices will sync here. So, if you preview a song on your iPhone, it will show in your preview history in iTunes.?

Search is now universal?
This isn't the most earth-shattering of news, but in iTunes 11 you have two main search areas: the store and your library. That's it. In previous versions you had to search separately for video, music, or podcasts. Now, it searches your entire local library, or the iTunes store for everything.

Also nice is the instant search results you get. Start typing a search, and iTunes starts delivering you results. Select what you want, and you're taken there directly. It's simple, but it works really well.

Apps get a list view for easy trimming
One of the most annoying things to do in older versions of iTunes was trimming down the apps downloaded on your computer. You had to do it in the Apps panel with large icons that seemed to take forever to load. Now you can do it with in a List View, and it supports the same basic sort options you get with music (Date Added, Purchase Date, Size, etc).

All you need to do is select the Apps tab, then click "List." This should come in really handy when you're cleaning out old apps you don't use anymore. Reader?shafnitz points out?this view has been around a little while, but if nothing else it's more prevalent now.

More from LifeHacker

Source: http://www.nbcnews.com/technology/gadgetbox/how-use-itunes-11s-new-features-bring-back-old-itunes-1C7361026

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Discover The Many Business Opportunities Available By Using A ...

The worldwide web is a powerful tool in so many ways. For those in business it is nothing less than revolutionary. It is now possible to sell, promote, publicize, and strategically market your company, your brand, and your products using the web. Each year seems to bring an innovative channel or trnd that helps executives in their marketing efforts.

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The world is getting faster"changes, modulations, and innovations are happening at a startling pace. Staying on top of the best ways to organize, interpret, and act on what you gather about the needs, desires, and demands of the market can be a challenge. But you do not have to go it alone. Vancouver Internet marketing firms provide you with the knowledge, ability, and skills you need to plan and implement an effective strategic marketing campaign. Internet marketing is the future, and Internet marketing Vancouver firms can help you seize that future.

The world is moving faster and Internet marketing is the future. Find out how a an Internet Marketing Vancouver can help you seize that future for your company

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Source: http://www.workoninternet.com/business/reviews/miscellaneous/220485-article.html

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